Review of Histamine Intolerance in Fibromyalgia, 2000-2025

A narrative review PDF summarizing evidence on histamine intolerance as a treatable subtype of fibromyalgia. The document, authored by João Protásio Netto and last updated in April 2026, analyzes literature from 2000 to 2025, including genetic, biochemical, and clinical studies. It reports findings such as a 74.5% prevalence of DAO deficiency-associated genetic variants in fibromyalgia patients and results from a randomized controlled trial with 100 participants.

Use Cases

• Reviewing genetic and biochemical evidence linking DAO deficiency to fibromyalgia based on the described literature synthesis.
• Analyzing clinical trial outcomes for DAO supplementation in fibromyalgia patients based on reported metrics like the Pain Catastrophizing Scale and Fibromyalgia Impact Questionnaire.
• Investigating associations between fibromyalgia and comorbid allergic or histamine-mediated conditions based on the described population studies involving 15,869 patients.

Strengths

• The review synthesizes evidence from a defined time range (2000-2025), including genetic association analyses, randomized controlled trials, and population-based observational research.
• Reports specific quantitative findings, such as a 74.5% prevalence of DAO deficiency-associated genetic variants in fibromyalgia patients and a randomized controlled trial with n=100.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and sharing.

Limitations

• The dataset is a single 585.8 KB PDF document, representing a limited scope of textual information rather than primary research data.
• Row count and column-level documentation are absent; the document's internal data structure and primary source data are not directly accessible.
• Description metadata is limited; actual data quality and the completeness of the reviewed literature require manual inspection of the PDF.

Provenance

Source

figshare

Collection Method

Narrative literature review

Time Range

2000-2025

Freshness

Last updated 2026-04-30 05:41:51