KHF and Rutin Effects on Pulmonary Fibrosis Mouse Model

A 917.1 KB Excel dataset from figshare, authored by Siyuan Zhu and last updated in April 2026. It likely contains experimental results from a study investigating the Kangxianhuanji Formula and rutin in treating acute exacerbation of idiopathic pulmonary fibrosis. The data supports findings on anti-inflammatory and anti-glycolytic effects via GLUT1 targeting.

Use Cases

• Validate network pharmacology predictions based on glycolysis-related pathways mentioned in the description.
• Analyze proteomic changes in a bleomycin-induced mouse model based on GLUT1 and HIF-1α expression.
• Correlate anti-inflammatory effects with lactate production data suggested by the description.
• Identify bioactive compounds in traditional herbal formulas using LC-MS/MS and molecular docking results.
• Assess therapeutic efficacy in lung injury models based on histopathology and cytokine level measurements.

Strengths

• Data is associated with a detailed methodological description including network pharmacology, proteomics, and molecular docking.
• The dataset is openly licensed under CC-BY-4.0, permitting reuse and redistribution.
• File size is 917.1 KB, indicating a focused and manageable dataset for analysis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely generated from experimental studies on a bleomycin-induced mouse model, using techniques like histopathology, immunofluorescence, quantitative proteomics, and LC-MS/MS.

Freshness

Last updated 2026-04-24 04:22:35; freshness should be verified.