Ketogenic Interventions on Sleep and Memory in Aged Rats

Arianna R. S. Lark published a dataset on figshare in April 2026 detailing a study on aged Fischer-344 rats. The research investigates the effects of ketogenic diet and β-hydroxybutyrate ester supplementation on sleep architecture, spatial memory, and oxidative stress markers. The dataset likely contains experimental results, including sleep stage metrics, cognitive task scores, and immunohistochemistry data.

Use Cases

• Analyze sex-dependent effects on REM sleep based on intervention type (KD or KE) mentioned in the description
• Model relationships between metabolic interventions and novel place recognition memory performance
• Correlate sleep bout metrics with molecular markers like lipid peroxidation (4-HNE) and TREM2 expression
• Compare EEG spectral analysis results (NREM delta, REM theta power) between intervention groups

Strengths

• Data includes p-values for significant findings (e.g., p=0.0152 for KE on REM sleep)
• Study design includes multiple interventions (KD, KE) and control groups over a 2-month period
• Analysis incorporates multiple modalities: sleep recordings, behavioral tasks, and postmortem immunohistochemistry

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data is specific to aged Fischer-344 rats, limiting generalizability to other species or age groups

Provenance

Source

figshare

Collection Method

Experimental study with implanted EEG/EMG electrodes, sleep scoring via AccuSleep, novel place preference task, and postmortem immunohistochemistry.

Freshness

Last updated 2026-04-10 06:01:30; freshness should be verified