Data Sheet 1: IGFBP3 Knockout Effects on Alcohol-Induced Liver Injury

334.3 KB of supplementary data from a study investigating Insulin-like Growth Factor Binding Protein 3 (IGFBP3) in alcoholic liver disease (ALD). The research, authored by Huimei Cai and shared under a CC-BY-4.0 license, includes analyses from in vitro AML12 cell experiments and in vivo liver-specific IGFBP3 knockout mouse models. The data likely contains measurements related to lipid accumulation, reactive oxygen species (ROS) generation, apoptosis, and signaling pathway activation via Akt/GSK3β and TMEM219/Caspase8.

Use Cases

• Validate findings on IGFBP3's role in alcohol-induced hepatocyte injury based on the described overexpression and knockout experiments.
• Analyze the relationship between lipid accumulation and apoptosis signaling pathways based on the Akt/GSK3β and TMEM219/Caspase8 mechanisms described.
• Compare in vitro cell line data with in vivo mouse model data based on the study's dual experimental approach.
• Investigate potential cross-talk between metabolic and apoptotic pathways in the liver based on the described paradoxical signaling effects.

Strengths

• Data is directly linked to a mechanistic study published on figshare, providing biological context.
• The dataset is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is very small at 334.3 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred from the associated paper.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Generated from laboratory experiments involving cell culture and genetically modified mouse models.

Freshness

Last updated 2026-05-15 04:26:28; freshness should be verified.