Data Sheet 1: Kv1.3 Channel Role in Organic Dust-Induced Neuroinflammation

A 3.1 MB PDF research data sheet from figshare, authored by Nyzil Massey and last updated in March 2026. It details experimental data on the role of the Kv1.3 potassium channel in neuroinflammation following organic dust exposure, using murine in vitro, ex vivo, and in vivo models. The study includes measurements of cytokines, reactive species markers, and protein expression levels.

Use Cases

• Analyzing the relationship between Kv1.3 expression and inflammatory markers like TNF-α and IL-6 based on the described experimental results.
• Studying oxidative stress pathways by examining data on NOX2 and nitrite levels mentioned in the description.
• Investigating microglial activation states using data from whole-cell patch-clamp recordings of Kv1.3 currents.
• Modeling the effects of pharmacological inhibition (PAP-1) on p38 MAPK phosphorylation and cytokine production as described.

Strengths

• Data is derived from multiple experimental models (in vivo, in vitro, ex vivo) as described.
• Includes specific molecular measurements such as cytokine levels, Kv1.3 expression, and p-p38 MAPK quantified via western blot.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The underlying raw data tables, column definitions, and row counts are not provided in the description.
• The 3.1 MB file size suggests the primary content is a document, limiting direct analysis of structured data.
• Data may reflect the specific experimental conditions and murine models described, which may limit generalizability.

Provenance

Source

figshare, author Nyzil Massey.

Collection Method

Experimental data from murine models exposed to organic dust extract, with analysis including RNA-seq, western blot, and patch-clamp.

Freshness

Last updated 2026-03-23 22:01:06.