Laptm4a Role in Renal Ischemia-Reperfusion Injury via UNC5B-AKT/mTOR

A research manuscript details the role of Laptm4a in renal ischemia-reperfusion injury (IRI) using mouse and cell models. The study, authored by Xiaoxiong Ma and published in 2026, employed methods including Western blotting, qPCR, and histopathological analysis to investigate the UNC5B-AKT/mTOR signaling pathway.

Use Cases

• Analyze Laptm4a expression patterns in kidney tissue from IRI mouse models to correlate with injury severity.
• Investigate the relationship between Laptm4a knockout and changes in inflammatory cytokine levels measured via ELISA.
• Study the suppression of the UNC5B-AKT-mTOR signaling pathway as a mechanistic link to apoptosis and tubular injury.

Strengths

• Research is recent, with a last update in March 2026.
• Data is derived from controlled experimental models including LAPTM4A knockout mice and HK2 cell lines.
• The study employs multiple validation methodologies like Western blotting, qPCR, and TUNEL assay.

Limitations

• The dataset is a single 11.0 MB DOC file, not a structured, machine-readable table, limiting computational analysis.
• No sample data or defined columns are provided, requiring manual extraction of figures and results.
• Findings are specific to preclinical mouse and HK2 cell models, which may not directly translate to human physiology.

Provenance

Source

Xiaoxiong Ma via figshare.

Collection Method

Experimental data from in vivo renal IRI models in LAPTM4A knockout mice and in vitro hypoxia-reperfusion models in HK2 cells.

Freshness

Last updated 2026-03-24.