Data Sheet 1_Ligature-induced periodontitis in mice potentially accelerates CD4+ T-cell se

A research document describes an experimental study on the link between periodontitis and systemic autoimmune disease. The study used BALB/c mice aged 5–42 weeks, inducing periodontitis via silk ligation and analyzing CD4+ T-cell senescence and its impact on collagen antibody-induced arthritis. The document was authored by Jinfeng Li and last updated on 2026-05-26.

Use Cases

• Study the acceleration of CD4+ T-cell senescence based on PD-1 and CD153 expression data described in the results.
• Investigate the senescence-associated secretory phenotype (SASP) cytokine levels in a mouse periodontitis model.
• Analyze differentially expressed genes related to senescence from the RNA-seq analysis of helper T cells.
• Model the exacerbation of rheumatoid arthritis based on adoptive transfer experiments of senescent T cells into nude mice.

Strengths

• The study design includes a specific age range for mice (5–42 weeks old) and a defined experimental periodontitis model (LIP).
• Results include specific cellular markers (PD-1, CD153) and a senescence indicator (SA β-gal) for analysis.
• The document is shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 153.1 KB DOCX file, which is a small document rather than a structured data repository.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Experimental study using a mouse model of ligature-induced periodontitis.

Freshness

Last updated 2026-05-26 06:03:41; freshness should be verified.