Limited Adaptability of Virtual Memory CD8 T Cells to Chronic Viral Infection

A research article published on figshare in May 2026 by Yamato Sajiki. The study characterizes the response of virtual memory CD8 T cells during chronic lymphocytic choriomeningitis virus infection in a mouse model. It describes mechanistic differences in exhaustion program engagement and cell differentiation compared to naïve CD8 T cells.

Use Cases

• Study the functional differences between naïve and virtual memory CD8 T cell subsets based on the described phenotypes.
• Investigate mechanisms of T cell exhaustion during chronic infection based on the analysis of TOX and TCF1 expression.
• Analyze the impact of PD-1 blockade therapy on different T cell subsets based on the described expansion limitations.
• Research the differentiation of KLRG1+PD-1- T cell populations in chronic viral settings.

Strengths

• File size is 1.0 MB, indicating a contained document.
• License is CC-BY-4.0, permitting broad reuse with attribution.
• The description provides a detailed mechanistic explanation of the biological findings.

Limitations

• The dataset is a single PDF file; the underlying raw data is not provided.
• Column-level documentation is absent; field semantics must be inferred from the article.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from a chronic lymphocytic choriomeningitis virus infection mouse model.

Freshness

Last updated 2026-05-15 05:27:41