Linker Peptide Effect on Mechanical Stability in Designed Polyprotein

A 119.9 KB Excel dataset from figshare, authored by Yanwei Wang and last updated on 2026-05 04. It contains data supporting the discovery of a 'Neighbor Peptide Effect' in the designed protein SuperMyo A339. The data likely includes results from single-molecule force spectroscopy and steered molecular dynamics simulations, showing how a specific linker peptide enhances mechanical stability.

Use Cases

• Analyzing the relationship between linker sequence and mechanical unfolding force based on the reported ~15% stability increase.
• Modeling interfacial hydrogen bond interactions based on the described contact-occupancy analysis of Ser117 and Lys218.
• Training or validating models for protein mechanical stability prediction based on the reported unfolding forces of ~350 pN and ~400 pN.
• Studying the effect of oligomerization on protein mechanics based on the comparison between monomer and tetramer data.

Strengths

• Data is associated with a specific, peer-reviewed scientific finding regarding the 'Neighbor Peptide Effect'.
• Includes quantitative results from two complementary methods: single-molecule force spectroscopy and steered molecular dynamics simulations.
• Released under a permissive CC-BY-4.0 license for open reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (119.9 KB), indicating a limited scope focused on a specific experimental result.

Provenance

Source

figshare

Collection Method

Experimental data from single-molecule force spectroscopy and computational data from steered molecular dynamics simulations.

Time Range

The data collection time range is not specified in the input.

Freshness

Last updated 2026-05-04 05:30:22; freshness should be verified.

Geography

The geographic coverage is not specified in the input.