Data Sheet 1: Immune Marker Profiles in Oral Contraceptive Users

392 premenopausal women from the SHIP-TREND-0 cohort were analyzed to link combined oral contraceptive use to systemic immune markers. The study found COC users had higher cortisol and CRP levels, along with altered chemokine and growth factor profiles. This dataset, authored by Johanna Klinger-König and shared under CC-BY-4.0, provides one of the first broad immune marker assessments in COC users.

Use Cases

• Modeling cortisol-dependent immune pathways based on the described indirect effects.
• Analyzing associations between oral contraceptive use and specific inflammatory markers like CRP.
• Investigating relationships between cortisol and vascular growth factors such as PDGF-AB/BB and VEGF-A.
• Comparing immune cell counts, such as monocytes, between COC users and non-users.

Strengths

• Dataset includes 392 premenopausal women, with 128 identified as COC users.
• Analysis includes a broad panel of immune markers, including cytokines, growth factors, and chemokines.
• Statistical results, including beta coefficients and p-values, are provided for key findings.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 719.7 KB DOCX document, which may not be a standard data format for analysis.

Provenance

Source

SHIP-TREND-0 cohort, a general population-based study.

Collection Method

Data analyzed using linear models and structural equation models.

Freshness

Last updated 2026-05-11 04:27:50; freshness should be verified.