Linking shox/shox2 Deficiency with fgfr3 and Natriuretic Peptides in Zebrafish

A zebrafish model study by Sandra Hoffmann, last updated in April 2026, investigates the mutual regulation of shox and shox2 genes and their relationship with fgfr3 and natriuretic peptide genes (nppa, nppb, nppc). The research examines expression patterns in whole embryos, fins, heart, and brain, revealing tissue-specific additive, synergistic, and antagonistic effects. The findings suggest implications for human SHOX deficiency and potential CNP therapy.

Use Cases

• Study tissue-specific gene regulation based on shox and shox2 expression patterns described in the study.
• Investigate relationships between shox deficiency and fgfr3 expression levels as indicated in the zebrafish model.
• Analyze natriuretic peptide gene activity (nppa, nppb, nppc) in response to shox/shox2 knockdown in fin and heart tissue.
• Explore potential cardiac disease markers based on the observed increase in nppb expression in heart tissue with shox/shox2 deficiency.

Strengths

• Data is associated with a specific research study examining gene interactions in multiple tissues (whole embryo, fins, heart, brain).
• Dataset is licensed under CC-BY-4.0, permitting open sharing and adaptation.
• File size is 1.9 MB, indicating a manageable download.

Limitations

• Dataset consists of a 1.9 MB DOCX file; the underlying data format and structure are not specified.
• Row count and column-level documentation are absent; data semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Sandra Hoffmann.

Collection Method

Likely contains experimental data from zebrafish gene expression studies as described.

Freshness

Last updated 2026-04-17 04:11:55; freshness should be verified.