Liposome Delivery Efficiency Data for Nucleic Acid Mimics in E. coli

A 466.6 KB PDF dataset from figshare, last updated May 2026, authored by João P. Santos. It describes experimental results on liposome formulations for delivering nucleic acid mimics into Escherichia coli bacteria. The data likely contains measurements of delivery efficiency and specificity for different lipid compositions and antibody conjugations.

Use Cases

• Compare delivery efficiency of different liposomal formulations based on lipid composition.
• Evaluate the impact of PEG-conjugated stabilizing lipids on delivery performance.
• Assess the species-specific targeting enhancement provided by anti-E. coli antibody conjugation.
• Analyze the relationship between antibody amount and delivery specificity.
• Investigate cytotoxicity results using the Galleria mellonella infection model.

Strengths

• Includes a specific result: a DOTAP/DOPE formulation achieved over 80% delivery efficiency.
• Reports a concrete finding: antibody conjugation reduced labeling in non-target bacteria by approximately 20%.
• States a clear outcome: formulations showed no detectable cytotoxicity in an in vivo model.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (466.6 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from laboratory research.

Freshness

Last updated 2026-05-28 06:20:06; freshness should be verified.