Long-term Consequences of Prenatal Saccharin Exposure in Adolescent Rats

A research document details a study on the sex-specific behavioral and molecular effects of gestational saccharin exposure in rats. The dataset, authored by Beatriz Pacheco-Sánchez and last updated in April 2026, includes findings from open field and elevated plus maze tests, alongside gene expression analysis in the prefrontal cortex. The file is 3.9 MB and is available under a CC-BY-4.0 license.

Use Cases

• Analyze sex-specific behavioral outcomes based on open field and elevated plus maze test results described in the study.
• Investigate molecular programing based on reported changes in endocannabinoid, glutamatergic, and GABAergic gene expression.
• Study developmental disruptors based on the described link between prenatal saccharin exposure and alterations in insulin signaling pathway proteins.

Strengths

• The study design is explicitly described, involving a 0.1% saccharin administration to pregnant rats throughout gestation.
• Results include specific behavioral metrics (time in arena center, open-arm entries) and named gene/protein targets (e.g., Dagla, Grin1, IRS-1).
• The dataset is openly licensed under CC-BY-4.0, facilitating reuse.

Limitations

• The primary data format is a DOCX document; underlying raw data tables are not directly accessible.
• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset's scale is small at 3.9 MB, suggesting it is primarily a summary document rather than a large raw data repository.

Provenance

Source

figshare

Collection Method

Experimental study involving behavioral testing and molecular analysis of rat prefrontal cortex tissue.

Freshness

Last updated 2026-04-30 05:40:38