Patient-Derived Pheochromocytoma Organoid Cultures from Two Patients

A pilot study by Marit F. van den Berg established long-term organoid cultures from two patients with pheochromocytoma, a rare neuroendocrine tumor. The organoids were cultured for 129 and 139 days, characterized for protein markers and hormone production, and last updated in March 2026. The dataset is a 2.5 MB document describing the methods and results of this proof-of-concept study.

Use Cases

• Modeling pheochromocytoma tumor biology based on the described organoid cultures.
• Studying the loss of chromaffin differentiation over time based on the reported decline in marker expression.
• Planning future drug screening experiments based on the established organoid platform.
• Investigating personalized therapeutic approaches for adrenal tumors based on patient-derived models.

Strengths

• Organoids were cultured for a long duration, with one line maintained for 139 days.
• Characterization includes multiple assays: histology, immunohistochemistry, immunofluorescence, qPCR, and LC-MS/MS.
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (2.5 MB) and is a descriptive document, not a structured data table.

Provenance

Source

figshare, authored by Marit F. van den Berg.

Collection Method

Organoids were generated from tumor tissue of two patients undergoing surgery and expanded under growth factor-enriched conditions.

Time Range

The study period is not specified; the data was last updated in March 2026.

Freshness

Last updated 2026-03-18 05:21:09; freshness should be verified.