Loss of SHP-1 in CD11c+ Cells Impairs Anti-Tumor Immunity: Mouse Model Data

Miguel Galán published this dataset on 2026-04-21. It contains data from a study investigating the role of the phosphatase SHP-1 in anti-tumor immunity using genetically modified mouse models. The data likely includes tumor growth measurements, survival data, and immune cell analysis from flow cytometry and single-cell RNA sequencing experiments.

Use Cases

• Analyzing the impact of SHP-1 depletion on tumor growth and survival based on mouse model experiments described.
• Studying changes in interferon response pathways in tumor-associated macrophages and cDC1s based on scRNA-seq analysis mentioned.
• Investigating alterations in MHC-II and co-stimulatory marker expression on antigen-presenting cells based on flow cytometry validation described.
• Evaluating the effect of SHP-1 loss on CD8+ T cell function during anti-PD1 treatment based on flow cytometry results mentioned.

Strengths

• Data is associated with a detailed biological study published on figshare.
• The dataset is licensed under CC-BY-4.0, permitting broad reuse with attribution.
• The file size is 12.9 MB, indicating a manageable download.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a PDF, which may not be in an analysis-ready tabular format.

Provenance

Source

figshare, author Miguel Galán.

Collection Method

Data generated from subcutaneous tumor inoculations in genetically modified mice, with analysis via flow cytometry and single-cell RNA sequencing.

Freshness

Last updated 2026-04-21 09:38:01; freshness should be verified.