Low-Dose Alteplase Therapy Outcomes for Prosthetic Valve Thrombosis in a UAE Hospital

Ziad Sadik's study presents clinical outcomes for 12 patients with prosthetic valve thrombosis treated with low-dose alteplase regimens at a quaternary care center in the United Arab Emirates. The dataset, last updated in March 2026, includes patient characteristics, treatment protocols, and clinical success rates. It is a retrospective cross-sectional study published under a CC-BY-4.0 license.

Use Cases

• Analyze the relationship between infusion protocol (slow vs. ultraslow) and clinical success rates based on the described treatment regimens.
• Model predictors of bleeding complications based on patient characteristics and total alteplase dose mentioned in the results.
• Compare outcomes for mitral versus aortic valve thrombosis based on the reported prevalence of each condition.

Strengths

• Includes specific clinical metrics: 50% success after first dose, 83.3% after second dose, and a 33.3% rate of bleeding complications.
• Provides detailed protocol information: infusion durations of 6 and 25 hours and a median total alteplase dose of 47.9 mg.
• Reports 100% patient survival at one-month follow-up.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The study's retrospective observational design and small sample size of 12 patients are noted limitations in the description.

Provenance

Source

Ziad Sadik via figshare

Collection Method

Retrospective cross-sectional study at a multispecialty quaternary care hospital.

Freshness

Last updated 2026-03-18 06:57:44; freshness should be verified.

Geography

United Arab Emirates