Low-Dose vs Standard-Dose IVIG in Myasthenia Gravis: A Single-Center Cohort Study

Data Sheet 1 from a prospective single-center cohort study by Haocong Luo, comparing low-dose and standard-dose intravenous immunoglobulin (IVIG) in 34 adults with generalized myasthenia gravis. The dataset includes clinical outcomes assessed using the MG-ADL and QMG scales at multiple time points over 12 weeks, along with infusion details and treatment indications. The data was last updated on April 28, 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Compare clinical improvement trajectories based on MG-ADL and QMG scores over a 12-week period.
• Analyze the relationship between cumulative IVIG dose (approximately 1.0 g/kg vs 2.0 g/kg) and patient outcomes.
• Investigate treatment indication patterns (e.g., acute exacerbation vs maintenance therapy) across different dosing cohorts.
• Evaluate short-term steroid-sparing effects by examining oral prednisone use over the study period.

Strengths

• Prospective study design with longitudinal data collected at 5 follow-up visits over 12 weeks.
• Includes 34 patient records with detailed clinical scores (MG-ADL, QMG) and treatment parameters.
• Data is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Small sample size of 34 patients, with baseline imbalance between the low-dose (n=21) and standard-dose (n=13) groups.
• Non-randomized, observational design limits causal inference, as noted by the author.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

Haocheng Luo via figshare

Collection Method

Prospective single-center cohort study.

Freshness

Last updated 2026-04-28 04:29:18; freshness should be verified.