Data Sheet 1: LUCAT1 Role in Head and Neck Squamous Cell Carcinoma

A 1.7 MB document details experimental findings on the long non-coding RNA LUCAT1's role in promoting cancer stemness in head and neck squamous cell carcinoma. Authored by Yifan Wen and uploaded to figshare in June 2026, the data sheet describes assays including sphere-forming and limiting dilution tests. The study identifies LUCAT1 as a competing endogenous RNA that sponges miR-128, affecting downstream targets like BMI1.

Use Cases

• Study the molecular regulation of cancer stem cells based on the described LUCAT1/miR-128/BMI1 axis.
• Validate findings on lncRNA function as a competing endogenous RNA (ceRNA) based on the described mechanistic model.
• Design in vitro and in vivo experiments targeting cancer stemness based on the described assays like sphere-forming and xenograft models.
• Investigate therapeutic targets for head and neck squamous cell carcinoma based on the described functional rescue assays.

Strengths

• Document is licensed under CC-BY-4.0, allowing for open sharing and adaptation.
• The description provides a detailed mechanistic explanation of the LUCAT1/miR-128 interaction and its functional validation.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The data is contained in a single DOCX file, which may require parsing to extract structured information.

Provenance

Source

figshare

Collection Method

Likely contains experimental data and analysis from a biomedical research study.

Freshness

Last updated 2026-06-03 04:47:10; freshness should be verified.