Lung scRNA-seq Data from Osteogenesis Imperfecta Mouse Model

Jennifer Zieba published this dataset on figshare in March 2026. It contains single-cell RNA sequencing data from the lungs of Col1a1^Aga2/+ (Aga2) mice, a model for osteogenesis imperfecta. The data reveals cellular mechanisms underlying lung abnormalities, including chronic inflammation and emphysematous phenotypes.

Use Cases

• Analyze cell type transitions and differentiation based on the described AT2 to AT1 cell transition and fibroblast activation.
• Investigate chronic inflammation pathways based on the reported increases in neutrophil/monocyte numbers and IL1B/TNF/NLRP3 pathway activation.
• Study gene expression changes associated with lung disease, such as decreased Scgb1a1 expression, across immune, epithelial, and fibroblast cells.

Strengths

• Data is derived from a specific and well-described mouse model (Col1a1^Aga2/+) for a moderate form of osteogenesis imperfecta.
• Includes samples from both young and adult mice, allowing for developmental analysis.
• Released under a permissive CC-BY-4.0 license for broad reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific computational tasks.

Provenance

Source

figshare, author Jennifer Zieba.

Collection Method

Single-cell RNA sequencing (scRNAseq) of lung tissue from a genetically modified mouse model.

Time Range

The dataset itself was published in 2026; the temporal coverage of the underlying biological samples is not specified.

Freshness

Last updated 2026-03-17 13:07:48.

Geography

Data is from a laboratory mouse model; geographic origin is not specified.