Macrophage and IL-6 Signaling in Multiple Myeloma Progression and Therapy Response

A 1.8 MB PDF research article authored by Xuanyou Liu and last updated on 2026-04-16. The study investigates the role of macrophages and IL-6 signaling in multiple myeloma progression and its impact on responses to metformin and CD126-targeting CAR-T cell therapy. It uses experimental data from THP-1-derived macrophages, CD126 CAR-T cells, and RPMI 8226 myeloma cells.

Use Cases

• Modeling tumor microenvironment interactions based on described co-culture experiments with macrophages, myeloma cells, and CAR-T cells.
• Analyzing the modulation of CAR-T cell killing activity based on findings of decreased efficacy after macrophage co-culture.
• Investigating drug effects on cell viability and receptor expression based on described metformin-induced reductions in CD126 expression and RPMI 8226 cell viability.

Strengths

• File size is precisely 1.8 MB.
• Dataset is licensed under CC-BY-4.0, permitting reuse with attribution.
• Last update timestamp is explicitly provided: 2026-04-16 05:17:21.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The primary data format is a PDF, which may require extraction or manual inspection to access structured data.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Xuanyou Liu

Collection Method

Experimental study using THP-1-derived macrophages, CD126 CAR-T cells, and RPMI 8226 myeloma cells.

Time Range

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Freshness

Last updated 2026-04-16 05:17:21; freshness should be verified.

Geography

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