Maraviroc Effects in a Mouse Model of Thyroid Eye Disease

669.8 KB of research data and analysis from a preclinical study on thyroid eye disease. The dataset, authored by Fahimeh Hashemi Arani and last updated in March 2026, documents the effects of the drug maraviroc on orbital inflammation, immune cell infiltration, and lipid metabolism in a mouse model of Graves' disease-associated TED.

Use Cases

• Analyze the therapeutic impact of a CCR5 antagonist based on descriptions of reduced immune cell infiltration and orbital remodeling.
• Study lipidomic profile changes in disease models based on reported reductions in triacylglycerols and elevated carnitines.
• Investigate correlations between immune markers and tissue pathology based on measurements of CCL5-positive cells, CD4+ T-cells, and F4/80+ macrophages.

Strengths

• Data is associated with a detailed, peer-reviewed-style methodology description.
• Dataset is openly available under a CC-BY-4.0 license for reuse.
• Last updated on 2026-03-18, indicating recent availability.

Limitations

• The dataset is a 669.8 KB DOCX file, suggesting limited raw data and a primary focus on textual results.
• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Data is from a single preclinical mouse model, which may limit generalizability.

Provenance

Source

figshare, author Fahimeh Hashemi Arani.

Collection Method

Data generated from a mouse model study involving immunization, drug treatment, serology, histology, immunohistochemistry, and untargeted lipidomics.

Freshness

Last updated 2026-03-18 07:35:48; freshness should be verified.