Mass Spectrometry Proteomic Profiles from Human Tauopathy Brains

A 2026 study by Alfi Raudatil Jannah presents proteomic data from postmortem human brain tissue. The dataset includes mass spectrometry results from 16 total subjects, with 4 each from Alzheimer's disease, corticobasal degeneration, progressive supranuclear palsy, and control groups. It was published on figshare under a CC-BY-4.0 license.

Use Cases

• Identifying differentially expressed proteins in tauopathies based on mass spectrometry results.
• Constructing protein-protein interaction networks based on the six highly interconnected mitochondrial proteins identified.
• Validating proteomic findings with transcriptomic data based on the complementary single-nucleus RNA sequencing results mentioned.
• Performing functional enrichment analysis based on pathways like oxidative phosphorylation and respiratory electron transport.

Strengths

• Includes validation via western blotting, immunohistochemistry, and single-nucleus RNA sequencing, as described.
• Reports 859 proteins with a P_FDR < 0.05 in the four-group comparison.
• Identifies a core network of six mitochondrial proteins (AK3, ATP5PD, COX7C, PPA1, PREP, UQCRC1) with P_FDR < 0.005.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The authors note the exploratory, hypothesis-generating nature of the study, suggesting findings require cautious interpretation.

Provenance

Source

figshare, authored by Alfi Raudatil Jannah.

Collection Method

Mass spectrometry analysis of total homogenates from postmortem human brain cortical regions.

Freshness

Last updated 2026-05-22 06:10:59; freshness should be verified.