Mast Cell and B Cell Interactions in Colorectal Cancer from Mouse and Human Studies

A research article investigating the role of mast cells in recruiting B cells within the colorectal cancer tumor microenvironment. The work includes findings from both a mouse model and human patient samples, focusing on the CCL20/CCR6 axis and TNF-α signaling. The document was authored by Viviana Valeri and last updated in April 2026.

Use Cases

• Study the relationship between mast cell activation and B cell recruitment in colorectal cancer based on the described experimental findings.
• Analyze the expression of CCR6 on B cells and CCL20 in tumor tissue as described in the results.
• Investigate the role of TNF-α from mast cells in sustaining CCL20 production by cancer cells based on the in vitro results.

Strengths

• Includes data from both a mouse model and human patient samples, as stated in the description.
• The research focuses on a specific molecular axis (CCL20/CCR6) and signaling factor (TNF-α).
• The dataset is openly licensed under CC-BY-4.0.

Limitations

• The primary data is embedded within a 1.6 MB PDF, requiring extraction for computational analysis.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Research study involving in vitro experiments and analysis of mouse and human samples.

Freshness

Last updated 2026-04-21 05:36:20; freshness should be verified.