Solanum Nigrum Anti-Psoriasis Mechanisms and Trigonelline Identification

Ya Chen's research data sheet investigates the therapeutic mechanisms of Solanum nigrum (SN) for psoriasis. It includes transcriptomic analysis of public datasets and clinical biopsies, results from imiquimod-induced dermatitis models, and chemical characterization via UPLC–MS. The study identifies trigonelline as a key active component inhibiting NLRP3 inflammasome signaling.

Use Cases

• Validate NLRP3 inflammasome activation in psoriasis based on transcriptomic data mentioned in the description
• Model the therapeutic effects of Solanum nigrum based on results from imiquimod-induced dermatitis models
• Identify bioactive plant compounds based on integrated chemical, biological, and computational analyses described

Strengths

• Includes analysis of public transcriptomic datasets and clinical skin biopsies
• Integrates results from primary and relapse psoriasis-like dermatitis models
• File size is 4.1 MB, indicating a detailed document

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is contained in a DOCX file, which may require extraction for computational analysis

Provenance

Source

Ya Chen via figshare

Collection Method

Research combining transcriptomic analysis, animal models, and chemical characterization

Freshness

Last updated 2026-04-24 04:22:22; freshness should be verified