Melatonin-Induced Restoration of the Intestinal Mucosal Barrier in IBD

48.4 KB document describes research on melatonin's role in inflammatory bowel disease. Qingyi Mao authored this study, which investigates melatonin's effects on gut microbiota and the SIRT1-LKB1-pAMPK pathway using patient samples, mouse models, and cell cultures. The dataset was last updated on May 5, 2026.

Use Cases

• Analyze the relationship between melatonin levels and IBD severity based on patient fecal metabolite measurements.
• Study the mechanistic impact of melatonin on gut microbiota composition, specifically Akkermansia and Desulfovibrio abundance.
• Investigate the SIRT1-LKB1-pAMPK signaling pathway activation in colitis models based on experimental results.
• Evaluate the protective effects of melatonin on intestinal antimicrobial peptides and tight junctions based on cell model data.

Strengths

• The research is based on a multi-model approach, including IBD patient samples, DSS-induced colitis mice, and LPS-stimulated NCM460 cells.
• The document provides a detailed mechanistic hypothesis involving the SIRT1-LKB1-pAMPK axis.
• The dataset is openly licensed under CC-BY-4.0.

Limitations

• The dataset is a 48.4 KB DOCX file, likely containing a research paper or summary rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Likely contains summarized research data from clinical measurements, animal models, and cell culture experiments.

Freshness

Last updated 2026-05-05 04:12:55; freshness should be verified.