Metabolite Biomarkers in Urine for Sarcopenia Screening from 200-Person Study

Featuring results from a cross-sectional study of 200 individuals aged 50–70 years, analyzing serum and urine metabolites associated with early sarcopenia. The study identified a panel of five metabolites—L-glutamic acid, xanthine, taurine, succinate, and L‐carnitine—detectable in urine. It provides a foundation for developing accessible screening tools for muscle health decline.

Use Cases

• Train a classifier to predict sarcopenia-related metabolic changes using the combined panel of L-glutamic acid, xanthine, taurine, succinate, and L‐carnitine biomarkers.
• Analyze correlations between metabolite levels in serum and urine samples from the subset of 60 participants with additional physical assessments.
• Investigate the association of metabolite panels with participant data from the International Physical Activity Questionnaire (IPAQ) and Short Physical Performance Battery (SPPB) scores.
• Validate the predictive performance of the identified metabolite panel for early alterations in muscle metabolism against dual-energy X-ray absorptiometry (DXA) measurements.

Strengths

• Data is derived from a clinical study of 200 individuals, providing a defined sample size.
• Includes a subset of 60 participants with comprehensive assessments including SPPB, DXA, and IPAQ.
• Identifies a specific panel of five metabolites (L-glutamic acid, xanthine, taurine, succinate, L‐carnitine) associated with the condition.

Limitations

• The dataset is very small at 103.7 KB, contained within a PDF, limiting direct analytical use without extraction.
• Sample size of 200 individuals and a 60-participant subset may limit statistical power for subgroup analyses.
• Cross-sectional design limits the ability to establish causal relationships or track metabolic changes over time.

Provenance

Source

figshare, authored by figshare admin frontiersin.

Collection Method

Targeted metabolomic analyses on serum and urine samples from a cross-sectional observational study.

Freshness

Last updated 2026-03-20.

Geography

General population, specific geography unknown.