Rat Cerebral Cortex Transcriptome and Metabolome Profiles After Subarachnoid Hemorrhage

Haoran Lu's dataset from 2026 provides transcriptome and metabolome profiles of the rat cerebral cortex following subarachnoid hemorrhage (SAH). It contains results from whole transcriptome sequencing and untargeted metabolomics assays, identifying differentially expressed genes and metabolites. The data reveals involvement of immune, inflammatory, and specific metabolic pathways in secondary brain injury post-SAH.

Use Cases

• Identify differentially expressed genes and metabolites based on transcriptomic and metabolomic assays mentioned in the description
• Analyze activation of immune and inflammatory pathways such as Complement and coagulation cascades based on the description
• Investigate affected metabolic pathways like Arginine and proline or Arachidonic acid metabolism described post-SAH
• Explore potential therapeutic targets based on the aberrant signals characterized in the study

Strengths

• Identifies 982 differentially expressed genes (DEGs) and 540 differentially expressed metabolites (DEMs) between sham and SAH 1d groups
• Reports 292 DEGs and 254 DEMs between SAH 1d and SAH 7d groups, providing temporal dynamics
• Integrates two omics layers (transcriptome and metabolome) for a multi-faceted analysis
• Data is shared under a permissive CC-BY-4.0 license

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is from a rat model, which may limit direct translation to human pathophysiology

Provenance

Source

Haoran Lu via figshare

Collection Method

Constructed using whole transcriptome sequencing and untargeted metabolomics assays on rat cerebral cortex tissue.

Freshness

Last updated 2026-04-28 14:40:40; freshness should be verified