Metal Concentrations in Paired Colon Cancer and Adjacent Tissues with Biomarker Data

Data Sheet 1 by Iman Al-Saleh, published on figshare in April 2026, contains data from a study of 50 adult patients with newly diagnosed primary colon cancer. The dataset includes concentrations of lead, cadmium, mercury, arsenic, chromium, and titanium measured in paired cancerous and non-cancerous colon tissue samples, along with associated global DNA methylation and oxidative DNA damage biomarker measurements.

Use Cases

• Compare toxic metal concentrations between cancerous and adjacent non-cancerous colon tissues based on the paired sample design.
• Model associations between tissue metal burden and global DNA methylation levels described in the study.
• Investigate relationships between tissue metal concentrations and circulating biomarkers of oxidative DNA damage, such as comet assay tail moment.

Strengths

• Data is from a study of 50 patients with paired tissue samples, enabling within-subject comparisons.
• Includes measurements for six specific metals (Pb, Cd, Hg, As, Cr, Ti) and multiple biomarker types.
• Published under a CC-BY-4.0 license, permitting open reuse and redistribution.

Limitations

• The dataset is very small at 45.1 KB; row count and column-level documentation are unknown.
• The description notes limited concordance between tissue-based metals and circulating biomarkers, suggesting complex relationships.
• Freshness should be verified as the last update date is in the future (2026-04-14).

Provenance

Source

Iman Al-Saleh via figshare.

Collection Method

Data collected from 50 adult patients undergoing surgical resection for primary colon cancer; metals measured via ICP-MS, biomarkers via ELISA and comet assay.

Time Range

Study period is not specified.

Freshness

Last updated 2026-04-14 05:36:40; freshness should be verified.

Geography

Geographic coverage is not specified.