Metal Compound Efficacy Against Chagas Disease: A 5-Year Systematic Review

113 metal-based compounds were analyzed for their anti-trypanocidal effect in a systematic review covering 22 articles. The review, authored by Vitor Klipel da Silva Bertolini and last updated in March 2026, compiles results on compounds centered on copper (17%), zinc (12%), and tin (9%). It outlines potential modes of action for 38% of the compounds, including mitochondrial disruption and enzyme inhibition.

Use Cases

• Prioritizing metal compounds for experimental validation based on reported anti-T. cruzi activity across life-cycle forms.
• Analyzing trends in metallodrug research based on the distribution of compounds by central metal (e.g., Cu, Zn, Sn).
• Investigating mechanisms of action for parasiticidal compounds based on described effects like reactive oxygen species generation.
• Identifying research gaps for drug development based on the reported lack of standardized efficacy testing methods.

Strengths

• Systematic methodology covering 22 articles from a defined 5-year period.
• Quantitative analysis of 113 distinct metal-based compounds.
• Provides specific percentages for compound distribution by central metal (e.g., Cu 17%).

Limitations

• The primary data is a review article (PDF); underlying experimental data is not directly accessible.
• Row count and column-level documentation for any compiled data are unknown.
• The description notes a lack of standardization in source methods, complicating direct compound comparison.

Provenance

Source

Vitor Klipel da Silva Bertolini via figshare

Collection Method

Systematic review of published scientific literature.

Time Range

Covers a 5-year period prior to the review's publication.

Freshness

Last updated 2026-03-18 06:57:56