Metformin Effects on Diabetic Amyotrophy in Rat Model via Oxidative Stress and Microbiota

Hejie Wang published this dataset on 2026-04-13. It contains results from a study exploring how metformin exacerbates diabetic amyotrophy in a streptozotocin-induced diabetic SD rat model. The 20.2 KB Excel file includes data from network toxicology, molecular docking, protein expression analysis (WB, ELISA, IHC), and 16S rDNA gene sequencing of fecal microbiota.

Use Cases

• Validate network toxicology predictions based on the 19 intersecting protein targets identified.
• Analyze gut microbiota alterations based on 16S rDNA sequencing results showing Desulfovibrio abundance changes.
• Model molecular docking interactions based on binding free energy and binding mode data for metformin with target proteins.
• Correlate oxidative stress markers based on WB and ELISA results for 3-nitrotyrosine expression in muscle tissue.
• Perform pathway enrichment analysis based on GO and KEGG results from the identified target proteins.

Strengths

• Data is openly licensed under CC-BY-4.0, facilitating reuse.
• Integrates multiple experimental methods: network analysis, molecular docking, protein assays, and microbiome sequencing.
• Includes statistically significant results (p < 0.001, p < 0.05) for key findings.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 20.2 KB, indicating limited scope.

Provenance

Source

Hejie Wang via figshare.

Collection Method

Experimental data from a streptozotocin-induced diabetic SD rat model, combined with computational network toxicology and molecular docking.

Time Range

Experimental timeframe is not specified.

Freshness

Last updated 2026-04-13 05:46:41; freshness should be verified.

Geography

Geographic origin of the study or data is not specified.