Metformin Effects on Glycolysis and Cytokines in Human Clinical Trial

Data Sheet 1 from a randomized cross-over trial of 34 healthy individuals, investigating the effects of metformin on glucose metabolism and stress-induced cytokines GDF15 and FGF21. The dataset includes results from a 42-hour fast protocol with and without metformin treatment, published by Kristoffer J. Kolnes on figshare. The data was last updated on March 18, 2026.

Use Cases

• Analyze the relationship between metformin treatment and glycolysis rates based on indirect calorimetry data.
• Model the effect of metformin on serum GDF15 levels using the reported concentration data.
• Compare cytokine responses (GDF15 vs. FGF21) to metformin treatment in human subjects.
• Correlate plasma metformin levels with metabolic outcomes like glucose utilization.

Strengths

• Data is from a controlled, randomized cross-over trial with 34 participants, providing a direct human in vivo comparison.
• Includes specific, statistically significant results (e.g., p=7.6x10^-13 for increased glycolysis) and cytokine concentration measurements (e.g., GDF15 1004±61 vs 607±89 ng/ml).
• Linked to a registered clinical trial (NCT01400191), enhancing traceability.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The primary data format is a 1.6 MB PDF, which may require extraction to access structured tabular data.

Provenance

Source

Kristoffer J. Kolnes via figshare

Collection Method

Data from a randomized, cross-over clinical trial involving human subjects and in vitro experiments with Caco-2 intestinal cells.

Freshness

Last updated 2026-03-18 05:34:51