Mouse and Human Data on Gut-Joint Immune Crosstalk in Arthritis

A 4.2 MB PDF document by Eva Schmid, last updated on 2026-05-20, presents research data on the gut-joint axis in rheumatoid arthritis. The study integrates mouse and human imaging mass cytometry and tissue sequencing to investigate endothelial and immune changes preceding arthritis. Findings suggest a mechanistic framework where barrier impairment and microbial translocation initiate autoimmunity.

Use Cases

• Study the temporal relationship between gut vascular permeability and synovial inflammation based on the collagen-induced arthritis model timeline.
• Analyze microbiota-specific serum IgG responses as a potential biomarker for increased bacterial antigen exposure.
• Investigate the therapeutic effects of gut-selective α4β7 integrin blockade (vedolizumab) and endothelial barrier enhancement (imatinib) on arthritis severity.
• Examine spatial epithelial–immune interactions and lymphoid activation in ileal tissues using imaging mass cytometry data.

Strengths

• Integrates data from both mouse models and human tissues, as described.
• Includes experimental results from therapeutic interventions (vedolizumab, imatinib).
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is a 4.2 MB PDF; underlying raw data files and column definitions are not provided.
• Row count and data structure are unknown, limiting suitability assessment for computational analysis.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Data likely generated through imaging mass cytometry (IMC) and tissue sequencing in mouse and human studies.

Freshness

Last updated 2026-05-20 05:44:24; freshness should be verified.