Mouse Lung Proteome and Cytokine Data for Millettia Speciosa Asthma Treatment Study

A proteomic dataset from a mouse model of allergic asthma, investigating the therapeutic effects of the herb Millettia speciosa. The data includes 179 differentially expressed proteins and cytokine measurements from bronchoalveolar lavage fluid. Author Hangrui Yang published the dataset on figshare in 2026 under a CC-BY-4.0 license.

Use Cases

• Identify protein biomarkers for asthma treatment response based on the 179 differentially expressed proteins.
• Investigate the role of CCL24 and other chemokines in eosinophilic inflammation as described in the results.
• Analyze immunometabolic pathway modulation, such as PPAR signaling and lipid transport, from the functional enrichment results.
• Validate hub protein networks involving Alb, Apoe, and Apoa1 for their role in immune regulation and metabolism.

Strengths

• Dataset is derived from a controlled experimental model using high-resolution data-independent acquisition (DIA) proteomics.
• Analysis identified a specific, key finding: complete suppression of the chemokine CCL24 in treated mice.
• Results are integrated with cytokine profiling data showing reductions in IgE, IL-4, IL-5, and IL-6.

Limitations

• The dataset is very small at 5.0 KB, suggesting it contains summary results rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• The mechanistic link to the gut-lung axis is noted as hypothetical and not directly investigated in the study.

Provenance

Source

figshare

Collection Method

High-resolution data-independent acquisition (DIA) lung proteomics integrated with cytokine profiling from an ovalbumin-induced mouse model.

Freshness

Last updated 2026-06-03 07:42:23; freshness should be verified.