Vitiligo Skin Biopsy Transcriptomic Profiles from 1 mm Punch Samples

Danique Berrevoet published a transcriptomic dataset from minimally invasive 1 mm skin biopsies of vitiligo patients. The dataset contains bulk RNA sequencing results from 105 skin samples across lesional, perilesional, and non-lesional skin, compared to healthy controls. It was last updated on 2026-05-14.

Use Cases

• Identify differential gene expression based on region-specific skin samples from vitiligo patients.
• Perform pathway-level analyses based on dysregulated signaling pathways like NOD-like receptor signaling.
• Predict candidate therapeutic compounds based on Connectivity Map analysis of the lesional transcriptional signature.
• Investigate cellular clearance mechanisms and metabolic reprogramming in vitiligo skin.

Strengths

• Dataset includes 105 skin biopsies, providing a substantial sample size for analysis.
• Uses a minimally invasive 1 mm biopsy technique, which likely reduces patient scarring compared to conventional methods.
• Compares multiple skin regions (lesional, perilesional, non-lesional) and healthy controls.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small in scale at 988.9 KB, indicating limited data volume.

Provenance

Source

figshare

Collection Method

Bulk RNA sequencing performed on skin biopsies from vitiligo patients and healthy controls.

Freshness

Last updated 2026-05-14 05:23:35; freshness should be verified.