MiR-34a Knockout Alzheimer's Mouse Model: Transcriptomic and Neuropathological Data

A 28.4 KB document by Junling Yang, last updated March 17, 2026, describes data from a study investigating miR-34a in Alzheimer's disease. The data likely includes results from Morris water maze cognitive tests, immunohistochemistry, bulk RNA-sequencing of the hippocampus, and qPCR on microglial cells. The study used a Tg-SwDI mouse model with constitutive miR-34a knockout.

Use Cases

• Analyze gene expression changes related to type I interferon signaling based on bulk RNA-seq results mentioned in the description
• Correlate cognitive performance from Morris water maze tests with amyloid-beta pathology data
• Investigate the relationship between miR-34a deficiency and interferon-stimulated gene (ISG) expression in microglia
• Study the effects of miR-34a on microglial activation states in a neurodegenerative disease context

Strengths

• Data is associated with a specific, peer-reviewed research methodology including RNA-seq and behavioral testing
• Released under a permissive CC-BY-4.0 license for reuse
• Focuses on a defined biological mechanism (miR-34a, type I interferon) in a transgenic mouse model

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download
• The 28.4 KB size suggests the primary data file is a summary document, not the underlying raw datasets
• Data may reflect experimental bias inherent to the specific mouse model and laboratory methods

Provenance

Source

Junling Yang via figshare

Collection Method

Data generated from laboratory experiments including transgenic mouse models, behavioral assays, immunohistochemistry, and RNA sequencing.

Time Range

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Freshness

Last updated 2026-03-17 13:08:21; freshness should be verified

Geography

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