miR-379-5p, KNDC1, and PEG10 Expression Data for Primary Ovarian Insufficiency Research

A bioinformatics dataset supporting a study on the molecular mechanisms of primary ovarian insufficiency (POI). It contains results from mRNA and miRNA microarray analyses identifying 590 differentially expressed genes and 610 differentially expressed miRNAs, validated with experimental assays. The dataset was authored by Jie Luo and last updated on 2026-05-12.

Use Cases

• Validate miRNA-mRNA interaction predictions based on identified differentially expressed genes and miRNAs.
• Train models to classify ovarian granulosa cell states based on gene expression signatures mentioned in the description.
• Conduct functional enrichment analyses on processes like cell cycle regulation and chromosome segregation referenced in the study.

Strengths

• Dataset is associated with a detailed experimental methodology including dual-luciferase reporter assays and rescue experiments.
• Identifies specific molecular targets (KNDC1 and PEG10) and a key regulator (miR-379-5p) with validated roles.
• Available under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific microarray platforms and patient cohorts used.

Provenance

Source

figshare

Collection Method

Data derived from POI-related mRNA and miRNA microarray datasets obtained from the GEO database, analyzed with bioinformatics methods and validated with laboratory experiments.

Freshness

Last updated 2026-05-12 22:01:59; freshness should be verified.