miR-489 and LAPTM4B in Breast Cancer: A Research Paper

A research paper by Gourab Gupta, last updated in May 2026, investigates the role of microRNA-489 in breast cancer. The 498.4 KB PDF presents findings on miR-489 expression, its correlation with patient survival, and its functional role in inducing immunogenic cell death by targeting LAPTM4B. The dataset is a single document published under a CC-BY-4.0 license on figshare.

Use Cases

• Study the association between miR-489 expression levels and patient survival outcomes in breast cancer cohorts.
• Investigate the mechanism of immunogenic cell death induction based on markers like calreticulin exposure and ATP release.
• Validate the miR-489–LAPTM4B regulatory axis as a potential therapeutic target in breast cancer models.

Strengths

• The dataset is a complete, peer-reviewed-style research paper with a clear mechanistic hypothesis and experimental validation.
• It includes specific biological findings, such as the correlation of miR-489 with improved patient survival and its functional target LAPTM4B.
• The data is openly shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a single 498.4 KB PDF document, not a structured data table; row and column counts are unknown.
• Column-level documentation is absent; field semantics must be inferred from the paper's text.
• Data may reflect the specific experimental and analytical biases inherent to the single study described.

Provenance

Source

Gourab Gupta via figshare

Collection Method

Experimental research involving analysis of breast cancer tissues, cell line functional assays, and molecular validation studies.

Freshness

Last updated 2026-05-20 05:44:23; freshness should be verified.