Pediatric Asthma-Obesity Comorbidity Circulating miRNA Profiles

43 pediatric blood samples were analyzed to identify microRNA signatures associated with asthma, obesity, and their comorbidity. The dataset, authored by Harshita Shailesh and last updated in May 2026, profiles circulating miRNAs using the NanoString nCounter platform. Results highlight seven dysregulated miRNAs linked to inflammatory pathways and lung function.

Use Cases

• Identify biomarker candidates for pediatric asthma stratification based on shared miRNA signatures.
• Investigate molecular links between obesity and asthma severity using miRNA expression profiles.
• Validate potential therapeutic targets in IL-4/IL-13 signaling pathways based on miRNA target analysis.
• Correlate miRNA dysregulation with clinical parameters like neutrophil counts and lung function.

Strengths

• Data includes samples from four distinct pediatric clinical groups (n=43 total).
• Analysis identified seven specific miRNAs consistently dysregulated across conditions.
• Correlations with clinical cytokine and lung function data were assessed.

Limitations

• The sample size is small, with groups ranging from 10 to 12 participants.
• Column-level documentation is absent; field semantics must be inferred after download.
• The cross-sectional design limits causal inference, as noted by the authors.

Provenance

Source

figshare

Collection Method

Whole blood samples analyzed via NanoString nCounter platform for miRNA profiling.

Freshness

Last updated 2026-05-13 04:57:55; freshness should be verified.