Mouse Hippocampal Dopamine and Memory Data from Mixed Metal Exposure Study

A toxicology study investigates spatial memory deficits and dopaminergic signaling in C57BL/6 mice exposed to lead, methylmercury, and cadmium for 28 days. The dataset includes results from Morris water maze tests and measurements of hippocampal dopamine levels, gene expression, and protein markers. Data was generated by author Haesoo Kim and published under a CC BY 4.0 license.

Use Cases

• Correlate Morris water maze performance metrics with hippocampal dopamine levels across exposure groups.
• Analyze expression changes in dopaminergic markers like tyrosine hydroxylase, dopamine transporters, and dopamine receptors between single and mixed metal exposures.
• Model the dose-response relationship of cognitive deficits relative to lead, methylmercury, and cadmium concentrations in drinking water.

Strengths

• Experimental design includes a control group and four distinct exposure groups for comparative analysis.
• Data integrates behavioral outcomes from the Morris water maze with molecular measurements of dopamine and related markers.
• Published under the permissive CC BY 4.0 license, allowing for broad reuse.

Limitations

• Dataset scale is limited, with a total file size of 2.6 MB, suggesting a small sample size.
• Study uses only male C57BL/6 mice, limiting generalizability to other sexes or strains.
• Data is contained in a DOCX file, which may require extraction and structuring for computational analysis.

Provenance

Source

Figshare, authored by Haesoo Kim.

Collection Method

Laboratory experiment exposing mice to metals in drinking water, followed by behavioral testing and molecular analysis.

Time Range

Experimental exposure period was 28 days.

Freshness

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Geography

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