Inflammatory Endothelial Dysfunction Model: A Human In Vitro Platform

Maria Cheremkhina developed a controlled in vitro model to study endothelial dysfunction under inflammatory stress. The model exposes endothelial cells to LPS-activated PBMCs under shear stress, mimicking systemic inflammation at the blood-material interface. The research paper, published on figshare in April 2026, details findings on endothelial confluence loss, leukocyte adhesion, and gene expression changes.

Use Cases

• Modeling endothelial dysfunction under inflammatory stress based on the described in vitro platform
• Analyzing leukocyte adhesion dynamics based on flow cytometry and microscopy data mentioned
• Studying gene expression of inflammatory mediators like IL-6, IL-8, and MCP-1 based on qPCR results
• Evaluating endothelial morphology and confluence changes under shear stress based on immunohistochemistry and SEM assessments

Strengths

• The dataset is a detailed research paper describing a specific experimental model and its results.
• The data is openly available under a CC-BY-4.0 license.
• The work directly addresses translational hurdles for biohybrid device development.

Limitations

• The dataset is a PDF document (345.3 KB), not a structured data file; column-level documentation is absent.
• Row count is unknown, which may limit suitability assessment for direct data analysis.
• The data may reflect the specific experimental bias inherent to the described in vitro model.

Provenance

Source

figshare

Collection Method

Experimental research conducted in a laboratory setting.

Freshness

Last updated 2026-04-09 05:15:29; freshness should be verified.