Influenza Virus Genomes from a Pediatric Hospital in Eastern China, 2024

Xiaoqing Sun's dataset contains 425 influenza virus genomes sequenced from 490 antigen-positive specimens collected in 2024 from a pediatric hospital in Qidong, eastern China. The data includes whole-genome sequences with at least hemagglutinin and neuraminidase segments for co-circulating A/H1N1, A/H3N2, and B/Victoria lineages. It captures genetic characteristics, phylogenetic clade assignments, and antiviral susceptibility markers like the oseltamivir resistance mutation NA-H275Y.

Use Cases

• Phylogenetic analysis of influenza virus clades based on whole-genome sequence data.
• Tracking antiviral resistance markers like NA-H275Y in A/H1N1 strains.
• Analyzing co-circulation patterns and activity peaks of influenza subtypes in a pediatric population.
• Identifying positively selected sites in hemagglutinin for different influenza lineages.

Strengths

• Includes 425 sequenced genomes from a defined collection of 490 specimens, yielding an 86.73% sequencing success rate.
• Provides specific clade assignments (e.g., 6B.1A.5a.2a for A/H1N1) and quantified resistance marker prevalence (3.65% for NA-H275Y).
• Captures data from a specific geographic location (Qidong, eastern China) and time period (2024) with two identified activity peaks.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (17.3 KB), indicating limited scope, likely a summary or processed results rather than raw sequence reads.
• Data may reflect geographic and temporal bias inherent to a single pediatric hospital in 2024.

Provenance

Source

Author: Xiaoqing Sun. Platform: figshare.

Collection Method

Influenza genome enrichment-based whole-genome sequencing performed on antigen-positive specimens from a pediatric hospital.

Time Range

2024

Freshness

Last updated 2026-04-16 05:22:47; freshness should be verified.

Geography

Qidong, eastern China