Cardiac Fibroblast and Immune Cell Co-Culture Data

A 1.8 MB PDF document authored by Zhongxiao Cong, last updated on May 12, 2026, presents research on cardiac fibrosis mechanisms. The study investigates how monocytes and neutrophils promote pro-fibrotic phenotypes in primary human cardiac fibroblasts through cytokines IL-6 and MIF, using cell-derived matrices and collagen gel contraction assays.

Use Cases

• Analyze cytokine regulation of fibroblast activity based on mentions of IL-6 and MIF.
• Study immune cell influence on extracellular matrix synthesis based on the described co-culture experiments.
• Investigate cardiac fibroblast migration and contraction assays based on described live imaging and gel contraction methods.
• Identify therapeutic targets for heart failure based on the described pro-fibrotic initiation mechanisms.

Strengths

• Data is openly licensed under CC-BY-4.0.
• The research focuses on primary human cardiac fibroblasts, which may increase physiological relevance.
• The study investigates specific cytokines (IL-6 and MIF) as active regulators.

Limitations

• The dataset is a 1.8 MB PDF; underlying raw data files are not provided.
• Column-level documentation is absent; field semantics must be inferred from the article.
• Row count is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

figshare

Collection Method

Experimental data from in vitro co-cultures of primary human cardiac fibroblasts with immune cell lines (THP-1, HL-60) and primary cells.

Freshness

Last updated 2026-05-12 05:42:34; freshness should be verified.