Case Report: Pediatric Mosaic DICER1 Mutation with Multiple Tumors

A single case report documents a 6-month-old boy diagnosed with four distinct tumors, including Wilms tumor and pleuropulmonary blastoma, linked to a mosaic DICER1 RNase IIIb hotspot mutation. The 756.9 KB document details the patient's surgical and chemotherapy treatments and a 27-month follow-up. This clinical text dataset was authored by Peiyi Yang and shared under a CC-BY-4.0 license on figshare.

Use Cases

• Literature review on DICER1-related tumor spectra based on the case report and review mentioned in the description
• Analysis of clinical management strategies for multi-tumor pediatric cases based on the described surgical and chemotherapy interventions
• Study of mosaic mutation presentations and outcomes based on the documented patient follow-up period

Strengths

• Provides detailed clinical narrative for a rare multi-tumor pediatric case linked to a specific DICER1 mutation (c.5113G>A p.E1705K).
• Includes a 27-month follow-up period, offering longitudinal outcome data.
• Shared under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a single case report (756.9 KB), representing a very limited sample size.

Provenance

Source

figshare

Collection Method

Clinical case documentation and literature review.

Time Range

Covers a patient case with a 27-month follow-up from initial diagnosis.

Freshness

Last updated 2026-04 27 04:11:17; freshness should be verified.

Geography

Patient location is not specified.