Data Sheet 1: MOTS-c Effects on Muscle Mass in C26 Cachexia Mouse Model

267.9 KB of data from a study investigating the mitochondrial-derived peptide MOTS-c in a cancer cachexia model. The dataset, authored by Nicholas A. Jamnick and shared under CC-BY-4.0, includes results from in vitro myotube experiments and in vivo studies with male mice inoculated with Colon-26 carcinoma cells. Measurements include body weight, organ and skeletal muscle masses, and molecular analyses of FOXO signaling, atrogene expression, and mitochondrial biogenesis markers.

Use Cases

• Assessing the therapeutic potential of MOTS-c based on reported muscle mass preservation (+12% quadriceps weight vs. C26 vehicle).
• Analyzing FOXO-driven catabolic signaling based on changes in pFOXO1 (+80%) and pFOXO3a (-39%).
• Investigating mitochondrial biogenesis based on PGC-1α protein restoration (+143%) and mRNA increase (+84.6%).
• Evaluating cachexia markers based on the upregulation of Atrogin-1 (+8.6-fold) and MuRF1 (+16-fold).

Strengths

• Includes specific quantitative results, such as a 12% preservation of quadriceps weight and an 80% increase in pFOXO1.
• Provides detailed methodological context for both in vitro (50 μM MOTS-c treatment) and in vivo (15 mg/kg/2x Day dosing) experiments.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (267.9 KB), indicating limited scope.

Provenance

Source

Nicholas A. Jamnick via figshare

Collection Method

Experimental data from in vitro cell culture and in vivo mouse model studies.

Freshness

Last updated 2026-05-25 04:32:46; freshness should be verified.