Multi-omics Analysis of Hypoxia and Immune Regulation in Septic Cardiomyopathy

A research document describing a multi-omics analysis of septic cardiomyopathy, identifying NFIL3 as a key hypoxia-associated immune regulator. The study, authored by Haibei Sun and shared on figshare under a CC-BY-4.0 license, integrates transcriptomic data from septic mouse myocardium and human peripheral blood cohorts. The file was last updated on April 30, 2026.

Use Cases

• Identifying diagnostic biomarkers for sepsis based on hypoxia-related gene expression patterns described in the study.
• Validating causal relationships between gene expression and sepsis risk using Mendelian randomization analysis as outlined in the document.
• Investigating macrophage-specific gene enrichment in septic myocardium based on single-cell analysis results.
• Studying the regulatory role of NFIL3 on inflammatory responses via NF-κB signaling as detailed in the experimental findings.

Strengths

• The study integrates bulk and single-cell transcriptomic data from mouse models and human cohorts.
• Identifies specific hub genes (NFIL3, TGM2, SDC4) with diagnostic performance validated in independent human datasets.
• Includes in vivo and in vitro experimental validation of mechanistic findings.

Limitations

• The primary data file is a 285.4 KB DOCX document, which is a small text file rather than a structured dataset.
• Row count and column-level documentation for any underlying data are unknown.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Haibei Sun

Collection Method

Transcriptomic profiling of septic mouse myocardium and analysis of human peripheral blood transcriptomic datasets.

Freshness

Last updated 2026-04-30 04:20:24; freshness should be verified.