Data Sheet 1_Multimodal evidence for the association between muscle mass and NAFLD: insigh

Weidong Xie's multimodal study investigates the relationship between muscle mass and non-alcoholic fatty liver disease (NAFLD). The analysis combines hospital-based data from 2,384 acute appendicitis patients (2016–2025), population survey data from 21,696 NHANES participants (1999–2018), and Mendelian randomization using GWAS summary data. Results suggest a consistent inverse association and potential causal link between higher muscle mass and lower NAFLD risk.

Use Cases

• Conducting causal inference analysis based on Mendelian randomization results.
• Validating clinical associations using hospital-based patient data and CT-defined NAFLD outcomes.
• Analyzing population-level trends in NAFLD risk factors using NHANES survey data.
• Investigating the relationship between sarcopenia markers like ASMI and liver disease.

Strengths

• Multimodal study design combining three distinct data sources: hospital records, national survey (NHANES), and genetic data.
• Large validation cohort of 21,696 participants from NHANES.
• Analysis includes statistical corrections (SIMEX, double-SIMEX) for measurement error.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the primary hospital dataset is unknown, which may limit suitability assessment.
• The primary data file is a 51.6 MB DOCX document, which may not be a standard structured data format.

Provenance

Source

figshare

Collection Method

Multimodal analysis combining hospital-based data, NHANES survey, and Mendelian randomization using GWAS summary data.

Time Range

Hospital data: 2016–2025; NHANES data: 1999–2018.

Freshness

Last updated 2026-05-25 22:02:15; freshness should be verified.

Geography

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