Data Sheet 1: Multiparameter T-Cell Immunoprofiling for Tuberculosis Exposure Detection

Data Sheet 1_Multiparameter antigen-specific immunoprofiling in subjects with negative IGRA and TST results with potential M. tuberculosis exposures.pdf contains flow cytometry data from a study of 54 IGRA-negative/TST-negative individuals, including 27 at risk for prior Mycobacterium tuberculosis exposure. The dataset, authored by Balaji Pathakumari and last updated on 2026-05-01, likely contains quantitative T-cell activation marker profiles from antigen stimulation assays. Results from this study were used to differentiate between potentially exposed and unexposed individuals.

Use Cases

• Training models to classify TB exposure status based on T-cell activation marker profiles.
• Validating flow cytometry assays for detecting antigen-specific immune responses.
• Identifying polyfunctional T-cell subsets as potential biomarkers for infection.

Strengths

• Includes data from 54 human subjects, providing a basis for statistical analysis.
• Focuses on a specific clinical question regarding IGRA/TST-negative individuals.
• Results include statistically significant ROC analysis with reported AUCs.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small in size (277.2 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Flow cytometric multiparameter profiling of T-cell activation markers in peripheral blood.

Freshness

Last updated 2026-05-01 05:25:06; freshness should be verified.