Multivariate GWAS Summary Statistics for Common Oral Diseases in Finnish Participants

Finnish participants contributed genome-wide association study summary statistics for dental caries, periodontitis, pulpitis, and temporomandibular disorders. The dataset includes results from multivariate GWAS and fine-mapping analyses identifying shared genetic loci. It was authored by Xiyao Ma and last updated on 2026-05-12.

Use Cases

• Identify shared genetic loci for oral diseases based on multivariate GWAS of a common oral genetic factor.
• Perform gene and pathway enrichment analysis based on results from cTWAS and MAGMA.
• Investigate tissue-specific genetic effects based on mapping to coronary artery and cultured fibroblasts.
• Study developmental origins of oral disease risk based on spatial mapping to embryonic tooth-germ compartments.

Strengths

• Analysis includes up to 500,000 participants, providing substantial statistical power.
• Multivariate GWAS identified 104 genome-wide significant SNPs aggregated into 96 independent loci.
• Fine-mapping refined results to 53 high-confidence causal variants.
• Dataset is licensed under CC-BY-4.0, allowing for broad reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the Finnish population source.

Provenance

Source

figshare

Collection Method

Analysis of GWAS summary statistics using High-Definition Likelihood, Genomic Structural Equation Modelling, SuSiE fine-mapping, cTWAS, and MAGMA.

Freshness

Last updated 2026-05-12 22:01:47; freshness should be verified.

Geography

Finland