L-NPDNJ Effects on Stenotrophomonas maltophilia Virulence and Biofilm Data

A research document by Maria Stabile, last updated May 29, 2026, details the anti-virulence effects of the compound L-NPDNJ against the opportunistic pathogen Stenotrophomonas maltophilia. The study includes in vitro and in vivo results from a Galleria mellonella infection model, measuring gene expression, biofilm formation, and cell adhesion.

Use Cases

• Analyzing the additive effects of L-NPDNJ with amikacin and tobramycin based on the described reduction in minimum inhibitory concentrations.
• Studying gene expression modulation related to antibiotic resistance and virulence based on the transcriptional changes mentioned.
• Modeling biofilm disruption and reduced adhesion based on the described decreases in biomass, metabolic activity, and cell surface hydrophobicity.
• Evaluating in vivo virulence reduction in infection models based on the dose-dependent results from the Galleria mellonella experiments.

Strengths

• License is CC-BY-4.0, permitting broad reuse with attribution.
• Description provides specific quantitative results, such as up to 90% reduction in cell adhesion and approximately 70% decrease in biofilm biomass.
• Research includes both in vitro assays and an in vivo Galleria mellonella infection model.

Limitations

• Dataset consists of a 2.6 MB DOCX file; the underlying structured data (e.g., raw measurements, gene counts) is not directly provided.
• Column-level documentation is absent; field semantics must be inferred from the manuscript text after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare, author Maria Stabile.

Collection Method

Experimental data from in vitro assays and an in vivo Galleria mellonella infection model.

Freshness

Last updated 2026-05-29 05:34:10; freshness should be verified.