Data Sheet 1: NAMs for Respiratory Uptake Assessment in a PARC Project

A project description document outlines the development of New Approach Methodologies for assessing respiratory uptake of chemicals. The document, authored by Pierre-André Billat and licensed under CC-BY-4.0, details a workflow combining in vitro and in silico methods, focusing on per- and polyfluoroalkyl substances. It was last updated on June 3, 2026, and is hosted on the figshare platform.

Use Cases

• Parameterizing inhalation PBK models based on in vitro respiratory uptake data
• Applying Read-Across techniques to infer permeability for untested PFAS chemicals
• Benchmarking in vitro NAM results against existing human in vivo data
• Developing workflows for quantitative in vitro to in vivo extrapolation in next-generation risk assessment

Strengths

• The document provides a detailed methodological plan for a specific research project focused on PFAS.
• It is openly licensed under CC-BY-4.0, permitting reuse and distribution.
• The description explicitly connects experimental and modeling approaches to fill knowledge gaps.

Limitations

• The dataset is a single 508.3 KB DOCX file, suggesting limited scope and no structured data.
• Column-level documentation is absent; field semantics must be inferred after download.
• The description is a project plan, not a dataset of experimental results or model parameters.

Provenance

Source

figshare

Collection Method

Project description document outlining planned experimental and modeling work.

Freshness

Last updated 2026-06-03 01:57:19; freshness should be verified.